Stem Cells Rehabilitate Diabetic Neuropathy
DOI:
https://doi.org/10.61856/7c8pf105Keywords:
Stem Cells, repair, Iraqi, Diabetic Foot, neuropathyAbstract
To report the effectiveness of stem cell treatment in diabetic neuropathy. This study recruited 83 Iraqi females from 45 to 73 years old who had NIDDM between August 31, 2020 and June 30, 2023. All of them had a "Diabetic neuropathy symptom score (DNS)" (grade 3–4) and a "Diabetic foot sensory neuropathy score" (grade 1-2). They all had HbA1c (10-13%) from 7 to 10 years. The patient/family provided informed permission when they visited the "Al Zahrawy Center for Stem Cells in Baghdad". For four treatment sessions (once every three weeks), Hamad dispersed stem cells around the tibial and deep peroneal nerves. Among 83 Iraqi females, 49 (59.1%) had a grade 4 "Diabetic neuropathy symptom score" upon presentation, which decreased to 24.2% in 20 females after three months of medication. Their "Diabetic foot sensory neuropathy (DNS)" was (54.3%) in 45 females at presentation and decreased to (21.8%) in 18 females after three months of treatment. The satisfaction rate for therapy was 74.6% for the "Diabetic neuropathy symptom score" and 78.3% for "Diabetic foot sensory neuropathy (DNS)". Stem cell therapy is a good treatment option for diabetic neuropathy. The researchers supported it and suggested a greater sample size in other places.
References
Al-Massri, K. (2020). Mesenchymal stem cells in chemotherapy-induced peripheral neuropathy: A new challenging approach that requires further investigations. Journal of Tissue Engineering and Regenerative Medicine, 14(1), 108-122. doi: https://doi.org/10.1002/term.2972
Sloan, G. (2021). Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy. Nat Rev Endocrinol, 17(7), 400-420. doi: https://doi.org/10.1038/s41574-021-00496-z
Hamad, A.M,, & Alhiti, H.A. R. (2022). Non-Obstructive Azoospermia Aided by Autologous Stem Cells. J Medical Case Repo, 4(1), 1-3. DOI:
https://doi.org/10.47485/2767-5416
Nalisa, D.L. (2022). Stem Cell Therapy for Diabetic Foot Ulcers: Theory and Practice. J Diabetes Res, 6;2022:6028743. https://doi.org/10.1155/2022/6028743.
Kubiak, C. (2020). Stem-cell-based therapies to enhance peripheral nerve regeneration. Muscle Nerve, 61(4), 449-459. doi: https://doi.org/10.1002/mus.26760
Hamad, A., & Alhiti, H. A. (2022). Stem Cell Therapy Modulates Cerebral Palsy: Case Report. J. Archives of Medical Case Reports and Case Study, 5(3), 118-122. https://doi.org/10.31579/2692-9392/118
Hamad, A., & Alhiti, H. A. (2023). Stem Cells and Nanosilver Saved Diabetic Foot. Journal of Liaquat University of Medical & Health Sciences, 21(5), 20-23. DOI: https://doi.org/10.22442/jlumhs.2023.00991
Røikjer J. (2021). Diabetic Peripheral Neuropathy: Diagnosis and Treatment. Curr Drug Saf, 16(1), 2-16. https://doi.org/10.2174/1574886315666200731173113
Jensen T. (2021). Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management. Brain, 28, 144(6), 1632-1645. doi: https://doi.org/10.1093/brain/awab079
Staff N. (2020). Pathogenesis of paclitaxel-induced peripheral neuropathy: A current review of in vitro and in vivo findings using rodent and human model systems. Exp Neurol, 324, 113121. doi: https://doi.org/10.1016/j.expneurol.2019.113121
Pantazis C. (2020). A reference human induced pluripotent stem cell line for large-scale collaborative studies. Cell Stem Cell, 29(12), 1685-1702.e22.doi: https://doi.org/10.1016/j.stem.2022.11.004.
Hamad, A., & Alhiti, H. A. (2021). Baghdad's first success in Bone Marrow Aspirate Concentrate procedure. Journal of Oran Faculty of Medicine, 5(2), 695-700. https://doi.org/10.51782/jfmo.v5i2.126
Lopes B. (2021). Peripheral Nerve Injury Treatments and Advances: One Health Perspective. Int J Mol Sci, 23(2), 918. doi: https://doi.org/10.3390/ijms23020918
Seghieri G. (2023). Metrics of Gender Differences in Mortality Risk after Diabetic Foot Disease. J Clin Med, 12(9), 3288. doi: https://doi.org/10.3390/jcm12093288
Downloads
Published
Issue
Section
License
Copyright (c) 2024 International Innovations Journal of Applied Science

This work is licensed under a Creative Commons Attribution 4.0 International License.







