Immunological and molecular study for TLR2 in patients with breast tumors

Abstract

A tumor is a mass of abnormal tissue. There are two types of breast cancer tumors: those that are non-cancerous, or ‘benign’, and those that are cancerous, which are ‘malignant’ Seventy (70) biopsy  of  breast tumors  patients women without chemotherapy for DNA extraction for genetic polymorphism of TLR2 and local immunity study for TLR2 , fifty (50) blood sample from healthy women as control group.  One hundred (100) blood sample from women with breast tumor for   polymorphism of TLR2 and   evaluated  immune markers (TLR2).The age  of women in this study ranging from (14-66) years in AL-Hilla-Teaching hospital , Imam Sadiq Hospital and  Marjan hospital  a period from September 2021 to October 2022.the result appearedthat By Enzyme Linked Immunosorbent Assay technique showed that the concentration of TLR2 in  serum patients were (9.953±4.606)  significantly increased  compare with control (6.774±3.855 )respectively, The concentrations of TLR2 in  serum patients were (5.599±3.550)  significantly different  compare with concentrations tissue (21.000 ±14.356 )respectively , For TLR2  196 to 174 del  genotyping the result was significantly only  deletion in (G, C , T ) between patients with chemotherapy and control ) at (p =0.003* , 0.0007* , 0.04*) respectively , also the result significantly for insertion of (G) between patients with chemotherapy and control ) at (p =0.01* )