The Role of Diabetes on Polycystic Ovary Syndrome (PCOS)
DOI:
https://doi.org/10.61856/d2dntb52Keywords:
Polycystic ovary syndrome Insulin Antibody (AIA) Insulin Insulin resistance EsterogenAbstract
The study focused on the insulin and its relationship with the Polycystic Ovary Syndrome (PCOS) in women. Where was it collected 44 samples of PCOS women and 46 samples as a control group. The results showed a significant decrease in progesterone at (P = 0.001), in women with PCOS. The findings in this study revealed the presence of a link between high insulin levels and polycystic ovarian syndrome, the statistical results demonstrate a positive significant association between insulin and estrogen at (p=0.001), and also found a significant negative correlation between other clinical parameter with insulin at, for those with the syndrome, due to the high level of insulin in their blood and the inability of female hormones and Insulin Antibody (AIA), to play their role in controlling the insulin and blood sugar level. Finally, the study showed that there is a new strong relationship between diabetes on PCOS and abortion.
References
Al-Taie, F. K., & Al-Jawadi, Z. A. (2019). The Impact of Obesity on Infertile Women with Polycystic Ovaries in Iraq. Rafidain Journal of Science, 28(2), 1-9. doi: 10.33899/rjs.2019.159964
Al-Ttaie, F. K., & Al-Jawadi, Z. A. M. (2021). Hormonal and biochemical study of the effect of obesity on women infertility. Journal of Health and Translational Medicine., 24(1): 53–57. doi: https://doi.org/10.22452/jummec.vol24no1.9
Bannigida, D. M., Nayak, B. S., & Vijayaraghavan, R. (2020). Insulin resistance and oxidative marker in women with PCOS. Archives of Physiology and Biochemistry., 126(2): 183–186.
Chang, S., & Dunaif, A. (2021). Diagnosis of Polycystic Ovary Syndrome: Which Criteria to Use and When? Endocrinology and Metabolism Clinics of North America., 50(1): 11–23.
Emanuel, R. H. K., Roberts, J., Docherty, P. D., Lunt, H., Campbell, R. E., & Möller, K. (2022). A review of the hormones involved in the endocrine dysfunctions of polycystic ovary syndrome and their interactions. Frontiers in endocrinology, 13, 1017468.
Glueck, C. J., & Goldenberg, N. (2019). Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics. Metabolism: Clinical and Experimental., 92: 108–120.
Gupte, A. A., Pownall, H. J., & Hamilton, D. J. (2015). Estrogen: An emerging regulator of insulin action and mitochondrial function. Journal of Diabetes Research., (2015):1-9.
Hu, C., Pang, B., Ma, Z., & Yi, H. (2020). Immunophenotypic profiles in polycystic ovary syndrome. Mediators of Inflammation.,( 2020): 1-10.
Lentscher, J. A., & Decherney, A. H. (2021). Clinical Presentation and Diagnosis of Polycystic Ovarian Syndrome. Clinical Obstetrics and Gynecology., 64(1): 3–11.
Lewandowski, K. C., Skowrońska-Jóźwiak, E., Łukasiak, K., Gałuszko, K., Dukowicz, A., Cedro, M., & Lewiński, A. (2019). How much insulin resistance in polycystic ovary syndrome? Comparison of HOMA-IR and insulin resistance (Belfiore) index models. Archives of Medical Science., 15(3): 613–618.
Merrheim, J., Villegas, J., Van Wassenhove, J., Khansa, R., Berrih-Aknin, S., Le Panse, R., & Dragin, N. (2020). Estrogen, estrogen-Like molecules and autoimmune diseases. Elsevier., 33(1): 1–48.
Moghetti, P., & Tosi, F. (2021). Insulin resistance and PCOS: chicken or egg? Journal of Endocrinological Investigation., 44(2): 233–244.
Rosenfield, R. L., & Ehrmann, D. A. (2016). The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The hypothesis of PCOS as functional ovarian hyperandrogenism revisited. Endocrine Reviews., 37(5): 467–520.
Saadia Z. (2020). Follicle Stimulating Hormone (LH: FSH) Ratio in Polycystic Ovary Syndrome (PCOS) - Obese vs. Non- Obese Women. Medical archives (Sarajevo, Bosnia and Herzegovina), 74(4), 289–293.
Witchel, S.F. Oberfield, S.E. Peña, A. S. (2019). Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment with Emphasis on Adolescent Girls. Journal of the Endocrine Society, 8(3): 1545–1573
Yang, Y., Liu, B., Wu, G., & Yang, J. (2021). Exploration of the value of progesterone and progesterone/estradiol ratio on the hCG trigger day in predicting pregnancy outcomes of PCOS patients undergoing IVF/ICSI: a retrospective cohort study. Reproductive Biology and Endocrinology., 19(1): 1–13.
Yousif, A. W.; Al-Jawadi, Z. A. (2022). Novel biochemical study of the impact of trace elements (zinc & magnesium) in polycystic ovary syndrome (PCOS). International Journal of Health Sciences, 6(S9): 1652–1658. https://doi.org/10.53730/ijhs.v6nS9.12637.
Zeng, X., Xie, Y. jie, Liu, Y. ting, Long, S. lian, & Mo, Z. cheng. (2019). Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity. Clinica Chimica Acta., 502: 214–221.
Zhou, Y. Ma, H. Liu, T. (2022). Effect of combined Qilin pill and estradiol valerate tablets on irregular menstruation in patients, and their serum levels of estradiol, progesterone and luteinizing hormone. Tropical Journal of Pharmaceutical Research, 21 (1): 201-206.
Zhu, J., Zhou, Y., Jin, B., & Shu, J. (2023). Role of estrogen in the regulation of central and peripheral energy homeostasis: from a menopausal perspective. Therapeutic advances in endocrinology and metabolism, 14, 20420188231199359.https://doi.org/10.1177/20420188231199359
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